The present study involves the preparation and evaluation of Chitosan based floating microspheres using Levetiracetam as model drug for prolongation of the gastric retention time. Levetiracetm is a BCS class-I drug hence it is absorbed rapidly from the stomach and having the half life of 6-7 Hrs. [1] so it is suitable candidate to formulate GRDDS. The microspheres were prepared by the simple emulsification phase separation technique using polymer Chitosan in fixed amount and varying the crosslinking agent Glutaraldehyde in varrient ratios. The shape and surface morphology of prepared microspheres were characterized by optical and scanning electron microscopy, respectively. The Percentage yield, Particle size distribution, Buoyancy percentage, Entrapment Efficiency and In vitro drug release studies were performed and drug release kinetics was evaluated. The prepared microspheres exhibited prolonged drug release (12h) and remained buoyant for > 8 h. The mean particle size increased and the drug release rate decreased at higher polymer concentration. In vitro studies demonstrated diffusion- controlled drug release from the microspheres.
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